Fig. 3. Evaluation of mutation patterns in TNBC cell lines, Hs578T/Pax and MDA-MB-231/Pax, post-therapy with paclitaxel using Ion Torrent PGM Machine and Ion AmpliSeq Cancer Hotspot Panel Pool v2. (A) Mutation patterns detected in the HS578T/Pax samples (B) Mutation patterns detected in the MDA-MB-231/Pax samples. (C) mutation legend: blue - drug response, green - benign, orange - likely pathogenic, red - pathogenic, purple - unknown significance (according to Climvar). Localization of mutations in each of the gene sequences for the most frequent mutated genes in TNBC cells for (D) Hs578T samples and (E) MDA-MB-231 samples.